Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) And High Platelet Levels Before Therapy as Prognostic Factors of Colorectal Cancer Stage III & IV
Yusuf Alfi Mulia1*, I Made Mahayasa2, Putu Anda Tusta Adiputra3, Nyoman Golden4, Ida Bagus Made Suryawisesa3, and I Made Mulyawan2
Abstract
Background: Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) and Platelets can reflect the balance between protumor inflammatory response and antitumor immune response. This examination is easily accessible, inexpensive, affordable and is known to be a prognostic predictor of CRC patients. Objective: to improve RNL, RTL and high platelet levels before therapy as prognostic factors for CRC stage III and IV at Prof. Dr IGNG Ngoerah Hospital Denpasar in 2017. Method: retrospective cohort analyzed descriptively, Chi-Square test, and Kaplan-Meier with the help of the Windows Statistical Package for the Social Sciences (SPSS) version 23 program. Results: Obtained as many as 144 respondents, 80 (55.6%) and 64 (44.4%) were alive, 26 were free from the disease, and 38 were still on treatment. The mean survival of 3 years overall survival was 24 months (95% CI 22-26 months; p<0.05). RNL> 2.2 obtained overall survival; RR 27.7 (95% CI 9.0 85.3; p<0.001) and 20-month mean survival (95% CI 17-22; p<0.001), disease-free survival RR 19.4 (95% CI 6.5-57.3; p<0.001). RTL > 130 obtained RR 92.4 (CI95% 20.5-415; p<0.001) and a mean survival of 19 months (95% CI 16-22; p<0.001), disease-free survival (95% CI 8.3-108.4; p<0.001). Platelet elevation >400,000 mm3 overall survival; RR 13.1 (95% CI 5.1-33.8; p<0.001) times and mean survival was 17 months (95% CI 14-19; p<0.001), disease-free survival 8.8 (95% CI 2-39.1; p=0.004). Conclusion: RNL, RTL, and high platelet levels before therapy are prognostic factors for CRC stage III and IV.
Keywords
colorectal cancer; platelets; RNL; RTL; survival
Cite This Article
Mulia, Y. A., Mahayasa, I. M., Adiputra, P. A. T., Golden, N., Suryawisesa, I. B. M., Mulyawan, I. M. (2023). Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) and High Platelet Levels Before Therapy as Prognostic Factors of Colorectal Cancer Stage III & IV. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 4: Jul-Aug 2023, Pages 523-532, URL: https://www.ijscia.com/wp-content/uploads/2023/07/Volume4-Issue4-Jul-Aug-No.465-523-532.pdf
Volume 4 | Issue 4: Jul-Aug 2023
