Association of Left Ventricular Global Longitudinal Strain (GLS) and NT Pro BNP Levels with Major Cardiovascular Events in Chronic Heart Failure Patients with Reduced Ejection Fraction
I Gusti Ayu Wijayanty Permatasari1, Luh Oliva Saraswati Suastika1*, I Nyoman Wiryawan1, Anak Agung Wiradewi Lestari2
Abstract
Background: Chronic heart failure (CHF) impairs the heart’s pumping ability due to structural or functional issues. Global Longitudinal Strain (GLS) is a precise method for assessing left ventricular function, while NT-proBNP is used to diagnose heart failure and predict outcomes. This study examines the relationship between GLS and NT-proBNP as predictors of major cardiovascular events in CHF patients with reduced ejection fraction. Methods: Chronic heart failure patients with LVEF ≤49% were observed in a cohort study. After echocardiography and NT-proBNP blood sampling, they were followed for 3 months to monitor rehospitalization and/or mortality. Baseline characteristics included demographic, clinical, comorbidity, laboratory, and echocardiographic data. GLS and NT-proBNP cutoff values were determined via ROC curves, and survival analysis was conducted using Kaplan-Meier curves and Cox Regression in SPSS 26.0. Results: A total of 65 samples were enrolled with no drop-outs. The optimal GLS cutoff was -7,5% (AUC 0,763, p=0,017) with 62,5% sensitivity and 86% specificity. NT-proBNP’s cutoff was 689 pg/mL (AUC 0,556; p=0,611) with 50% sensitivity and 87,7% specificity. Survival analysis showed lower survival rates in patients with GLS ≥-7,5% (66,7% vs. 92,5%; p=0,022) and NT-proBNP ≥689 (63,6% vs. 92,6%; p=0,012). However, neither GLS ≥-7,5% nor NT-proBNP ≥689 pg/mL were significant independent predictors of major cardiovascular events within 3 months. Higher LAVI (≥41 ml/m2) was found to be a significant independent predictor, associated with GLS ≥-7,5 (r -0,329; p=0,007), high NT-proBNP (r 0,632; p=0,03), EF (r -0,610; p<0,001), E/e’ (r -0,32; p=0,014), and medial E (r 0,28; p=0,024).
Keywords
GLS; NT-proBNP; chronic heart failure; major cardiovascular events
Cite This Article
Permatasari, I. G. A. W., Suastika, L. O. S., Wiryawan, I. N., Lestari, A. A. W. (2024). Association of Left Ventricular Global Longitudinal Strain (GLS) and NT Pro BNP Levels with Major Cardiovascular Events in Chronic Heart Failure Patients with Reduced Ejection Fraction. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 4: Jul-Aug 2024, Pages 804-815, URL: https://www.ijscia.com/wp-content/uploads/2024/08/Volume5-Issue4-Jul-Aug-No.651-804-815.pdf
Volume 5 | Issue 4: Jul-Aug 2024
