High Systemic Immune-Inflammation Index is Associated with Low Mid-Upper Arm Circumference and High Malnutrition Universal Screening Tool Score in Non-Small Cell Lung Cancer Patients
Edric Chandra1, Ida Ayu Jasminarti Dwi Kusumawardani1*, Agustinus I Wayan Harimawan2, Ni Wayan Candrawati1, I Gusti Ngurah Bagus Artana1, Ni Luh Putu Eka Arisanti1, Ida Bagus Ngurah Rai1
Abstract
Background: Non-small cell lung cancer (NSCLC) accounts for 82% of all lung cancer-related fatalities worldwide in 2020. Inflammation is a characteristic feature of all malignancies, including lung cancer, and it can worsen nutritional status and result in malnutrition. In order to evaluate inflammation, nutritional status, and malnutrition risk, the systemic immune-inflammation index (SII), mid-upper arm circumference (MUAC), and malnutrition universal screening tool (MUST), are chosen, respectively. Methods: From August to October 2023, an analytical observational study employing a cross-sectional design was conducted at Prof. Dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar on patients diagnosed with NSCLC. SII was used for the association with MUAC and MUST score by using bivariate analysis and logistic regression. Results: The total number of participants comprised 63 individuals. The bivariate analysis yielded inconclusive findings regarding the relationship between SII and MUAC; however, the multivariate analysis identified a significant relationship (p=0.033, odds ratio 4.197, 95% CI 1.119–15.735). SII was significantly associated with the MUST score, according to the findings of bivariate analysis (p=0.011; odds ratio of 4.675; 95% CI: 1.345–16,255). SII was an independent risk factor for a higher MUST score in NSCLC patients, according to a multivariate analysis (p=0.015, odds ratio: 4.675). Conclusion: An association has been observed between high SII and low MUAC, as well as between SII and MUST score ≥ 1, among patients diagnosed with NSCLC at Prof. Dr. I.G.N.G. Ngoerah Hospital.
Keywords
inflammation index; nutrition; non-small cell lung cancer
Cite This Article
Chandra, E., Kusumawardani, I. A. J. D., Harimawan, A. I. W., Candrawati, N. W., Artana, I. G. N. B., Arisanti, N. L. P. E., Rai, I. B. N. (2024). High Systemic Immune-Inflammation Index is Associated with Low Mid-Upper Arm Circumference and High Malnutrition Universal Screening Tool Score in Non-Small Cell Lung Cancer Patients. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 5: Sep-Oct 2024, Pages 863-868, URL: https://www.ijscia.com/wp-content/uploads/2024/09/Volume5-Issue5-Sep-Oct-No.658-863-868.pdf
Volume 5 | Issue 5: Sep-Oct 2024
