The Interplay Between Genetic, Environmental, and Microbiome Factors in the Development of Obesity: A Comprehensive Literature Review
Dzaky Ramadhan Hidayat1,2, Fatita Rachma Laudira1, Anggie Dewi Pitaloka1, Fesli Fadhila Ramadhani Saputro1, Sintia Wahyu Arifah1
Abstract
Obesity is a multifactorial condition that primarily occurs due to genetic, environmental, and microbiome-related factors. This broad-based review attempts to deliberate on how these varying aspects come together and determine the risk and the case of obesity. It has been shown that genetic predisposition leads to obesity outcomes. Environmental factors including dietary habits, exercise, and lifestyle are engaging with the genes, either being a persuasor or a deterrent to obesity. Emerging research highlights the critical role of the gut microbiome in modulating metabolism, inflammation, and energy balance, further complicating the obesity landscape. Studies demonstrate that microbial dysbiosis can drive increased fat storage and insulin resistance, often in conjunction with genetic and dietary factors. This review integrates evidence from genetic, environmental, and microbiomic attention with inseparable relationships of the factors. On top of this, we discuss possible treatment approaches that utilize modulation of the microbiome and individualized strategies aimed at the gene-environment-microbiome interplay. The review highlights the importance of integrative, multi-dimensional approaches to understanding and managing obesity, offering insights into future research and personalized treatment strategies.
Keywords
obesity; gut microbiome; genetics; environmental factors; personalized medicine; metabolic disease.
Cite This Article
Hidayat, D. R., Laudira, F. R., Pitaloka, A. D., Saputro, F. F. R., Arifah, S. W. (2024). The Interplay Between Genetic, Environmental, and Microbiome Factors in the Development of Obesity: A Comprehensive Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 5: Sep-Oct 2024, Pages 932-941, URL: https://www.ijscia.com/wp-content/uploads/2024/09/Volume5-Issue5-Sep-Oct-No.668-932-941.pdf
Volume 5 | Issue 5: Sep-Oct 2024
