The Relationship Between Platelet to Lymphocyte Ratio (PLR), Monocyte to Lymphocyte Ratio (MLR), Neutrophil to Lymphocyte Ratio (NLR), and Albumin Levels with The Severity of Community-acquired pneumonia (CAP) in Hospitalized Elderly Patients
Novinna Kusumawati1, Ni Luh Putu Eka Arisanti1*, Ni Ketut Rai Purnami2, Ida Ayu Jasminarti Dwi Kusumawardani1, Ni Wayan Candrawati1, Putu Andrika3, and Ida Bagus Ngurah Rai1
Abstract
Background: Community-acquired pneumonia (CAP) is a lung infection that often affects elderly patients and can be severe. Laboratory parameters, including platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), and albumin, have been linked to the prognosis of various infectious diseases. However, the relationship between these parameters and the severity of CAP in elderly patients is not yet fully understood. Methods: This is an analytic observational study with a cross-sectional design that involved 125 elderly patients (≥60 years old) with CAP who were hospitalized at Prof. Dr. I.G.N.G. Ngoerah Hospital between January and December 2023. The study collected demographic data, nutritional status, smoking status, and laboratory parameters (PLR, MLR, NLR, and albumin) from electronic medical records. The severity of CAP was assessed based on the 2019 IDSA/ATS criteria. Receiver operating characteristic (ROC) analysis was performed to determine the optimal cut-off point of laboratory parameters. Proportion comparison analysis and multivariate logistic regression were used to evaluate the association between laboratory parameters and the severity level of CAP. Results: Of a total of 125 study subjects, 48 (38.4%) had severe CAP. NLR values ≥9.84 with RR 15.242 (95% CI 4.999-46.475; p<0.001) and albumin values <3.295 g/dL with RR 5.407 (95% CI 2.630-11.115; p<0.001) were significantly associated with the severity of CAP in hospitalized elderly patients. Multivariate analysis showed that NLR had HR 37.426; (95% CI 9.295-150.694; p<0.0001) and albumin had an HR value of 3.747 (95% CI 1.149-12.221; P=0.029) which was significantly associated with the severity of CAP in hospitalized elderly patients after adjusting for confounding factors. Conclusions: High NLR values and low albumin values may be potential predictors for identifying elderly patients with CAP who are at risk for severity. These findings emphasize the importance of assessing laboratory parameters in managing CAP in the elderly population.
Keywords
CAP; elderly; severity.
Cite This Article
Kusumawati, N., Arisanti, N. L. P. E., Purnami, N. K. R., Kusumawardani, I. A. J. D., Candrawati, N. W., Andrika, P., Rai, I. B. N. (2024). The Relationship Between Platelet to Lymphocyte Ratio (PLR), Monocyte to Lymphocyte Ratio (MLR), Neutrophil to Lymphocyte Ratio (NLR), and Albumin Levels with The Severity of Community-acquired pneumonia (CAP) in Hospitalized Elderly Patients. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 5: Sep-Oct 2024, Pages 976-983, URL: https://www.ijscia.com/wp-content/uploads/2024/10/Volume5-Issue5-Sep-Oct-No.675-976-983.pdf
Volume 5 | Issue 5: Sep-Oct 2024
