Form Deprivation Myopia Effect in Axial Length and Refraction Status in Oryctolagus cuniculus as Animal Model: In Vivo Experimental Study

Kamila Putri Rahmani^1*, Luki Indriaswati², and Gwenny Ichsan Prabowo³

Abstract

Background: Myopia is an ocular disorder that occurs around the world with unknown underlying causes. FDM is a method that is conducted as experimental myopia research in animal models. The deprivation in certain periods is resulting myopic eyes and changes that occur anatomically or molecularly. Objective: Observing the effect of Form Deprivation Myopia (FDM) on axial length and refraction status in Oryctolagus cuniculus (rabbits). Method: A total of 16 rabbits were divided into two groups selected randomly. Deprivation for four weeks is given at the right eye of the treatment group with an adhesive bandage. After four weeks of deprivation, the axial length and refraction status are examined to see if the differences occurred compared to the initial condition. Results: The axial length parameter after four weeks of deprivation shows the treatment group is significant from week 0 to week 4 (p= 0.002). The control group shows significant results (p=0.034). However, the mean value of the treatment group is larger than the control group (0.6500>0.3812). The refraction status results after four weeks of deprivation show the difference is significant in the treatment group (p= 0.000). No significant result from the control group (p>0.05). Conclusion: The effects from the result of 4 weeks of deprivation in the rabbit eye, such as axial length elongation and status refraction changes, indicate myopia condition. Although the control group also experienced changes in axial length and status refraction, the result was still not as significant as the treatment group.

Keywords

animal model; axial length; Form Deprivation Myopia (FDM), refraction status.

Cite This Article

Rahmani, K. P., Indriaswati, L., Prabowo, G. I. (2024). Form Deprivation Myopia Effect in Axial Length and Refraction Status in Oryctolagus cuniculus as Animal Model: In Vivo Experimental Study. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 5: Sep-Oct 2024, Pages 1003-1007, URL: https://www.ijscia.com/wp-content/uploads/2024/10/Volume5-Issue5-Sep-Oct-No.679-1003-1007.pdf

Volume 5 | Issue 5: Sep-Oct 2024