The Effect of Pulmonary Rehabilitation on Length of Hospitalization, Alveolar-Arterial Oxygen Gradient, and Interleukin-8 Levels in Hospitalized Non-Severe Community-Acquired Pneumonia Patients at Prof. I.G.N.G Ngoerah General Hospital
I Wayan Angga Suamerta Putra1, Ni Luh Putu Eka Arisanti1*, Luh Kamiati2, Ni Wayan Candrawati1, Ida Ayu Jasminarti Dwi Kusumawardani1, and I Desak Putu Agung Krisdanti1
Abstract
Background: Community-acquired pneumonia is an acute infection of the lung parenchyma that can lead to inflammatory fluid exudation, thereby impairing oxygen diffusion. Pulmonary rehabilitation is a series of therapies aimed at enhancing respiratory efficiency, lung expansion, respiratory muscle strength, and clearing respiratory system secretions. Interleukin-8 (IL-8) is a pro-inflammatory cytokine that reflects epithelial injury in the respiratory system. The alveolar-arterial oxygen gradient (A-a O2) measures the oxygen difference between alveoli and arteries, which is clinically important for assessing diffusion function and distinguishing between pulmonary and extra-pulmonary causes of hypoxemia. Methods: This study is a systematic, single-center randomized controlled trial (RCT) conducted at Prof. I.G.N.G. Ngoerah Hospital from July to September 2024. The study examined the effect of pulmonary rehabilitation on length of hospitalization, A-a O2 gradient, and IL-8 levels. Results: The length of group P1 (pulmonary rehabilitation and conventional therapy) was significantly shorter by 1.16 days (p = 0.013). Pulmonary rehabilitation significantly reduced A-a O2 and IL-8 levels, with a median decrease from day one to day five of 16.00 mmHg in group P1 and 7.50 mmHg in group P2 (conventional therapy) (p = 0.000). IL-8 levels also significantly decreased, with a median reduction of 41.81 pg/ml in group P1 and 18.35 pg/ml in group P2 (p = 0.025). Conclusion: The combination of pulmonary rehabilitation and antibiotic therapy effectively reduces the length of hospitalization, A-a O2 levels, and IL-8 in hospitalized non-severe community-acquired pneumonia patients.
Keywords
non-severe pneumonia; pulmonary rehabilitation; length of hospitalization; IL-8, A-a O2.
Cite This Article
Putra, I. W. A. S., Arisanti, N. L. P. E., Kamiati, L., Candrawati, N. W., Kusumawardani, I. A. J. D., Krisdanti, I. D. P. A. (2024). The Effect of Pulmonary Rehabilitation on Length of Hospitalization, Alveolar-Arterial Oxygen Gradient, and Interleukin-8 Levels in Hospitalized Non-Severe Community-Acquired Pneumonia Patients at Prof. I.G.N.G Ngoerah General Hospital. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1058-1065, URL: https://www.ijscia.com/wp-content/uploads/2024/11/Volume5-Issue6-Nov-Dec-No.689-1058-1065.pdf
Volume 5 | Issue 6: Nov – Dec 2024
