Antibiotic Resistance in Bacteria on Burn Wound Patients: A Review of Current Literature
Nasywaa Tiara Dewani1, Agus Santoso Budi2*, Eko Budi Koendhori3
Abstract
Burn injuries are commonly complicated by health-associated infections (HAIs), and bacterial infections are one of the major threats to recovery in burn patients. In these patients, early and appropriate antibiotic therapy is critical because delayed treatment can increase mortality. Diagnosis of infection in these patients is also challenging because the symptoms of burn- induced inflammation overlap with those of infection. Empiric antibiotic therapy is often initiated in response to clinical manifestations, but it is important to modify the treatment regimen once microbiological findings are obtained. Commonly used antibiotics for the treatment of infections related to burns include cefotaxime, amikacin, and cefuroxime, which exhibit broad spectrum activity against a wide range of pathogens, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. Despite their activity, an increased incidence of antibiotic resistance, including multidrug resistance, has made the treatment challenging. Resistance mechanisms, such as efflux pumps, inactivation by enzymes, and target-site modifications, have a key role in the development of antibiotic-resistant bacteria. For this reason, susceptibility testing is crucial, and treatment should be altered based on the obtained results. It is of paramount importance to understand bacterial resistance dynamics and the correct use of antibiotics in order to treat burn patients effectively, especially within the hospital setting, where nosocomial infections are common. The increasing apprehension regarding antibiotic resistance underscores the necessity for ongoing monitoring and the innovation of new antimicrobial approaches to address resistant pathogens in the context of burn treatment.
Keywords
burn injuries; bacterial infections; antibiotic resistance.
Cite This Article
Dewani, N. T., Budi, A. S., Koendhori, E. B. (2024). Antibiotic Resistance in Bacteria on Burn Wound Patients: A Review of Current Literature. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1369-1374, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.734-1369-1374.pdf
Volume 5 | Issue 6: Nov – Dec 2024
