Histopathology of Interstitial Fibrosis Degree Following Administration of East Java Nano Propolis in Adenine-Induced Chronic Kidney Disease Model (Rattus norvegicus)
Muhammad Farid Yudistira Harimurti1, Joni Susanto2*, Eko Budi Koendhori3, Tri Hartini Yuliawati2, Nathan Adia Abiati1
Abstract
Introduction: Chronic kidney disease is a worldwide health concern, with chronic inflammation and fibrosis formation as its key pathological features. Current interventions for chronic kidney disease show substantial side effects and a high cost that poses a social and economic burden. Propolis is a natural product from bees that exhibits anti-inflammatory and antioxidant effects, making it a potential therapy option. Objective: This experimental study emphasizes the relationship between varying dosages of propolis and interstitial fibrosis degree in chronic kidney disease models. Method: A true experimental post-test-only controlled group study to asses east java nano propolis effects regarding interstitial fibrosis degree in adenine-induced chronic kidney disease model. The rats are divided into four groups: Group K0 (5 rats without daily nano propolis administration), group P1 (5 rats with 100 mg/kg WB/day intervention), group P2 (6 rats with 200 mg/kg WB/day intervention), and group P3 (5 rats with 300 mg/kg WB/day intervention). Result: Group P2 exhibits a significant difference towards K0 (p=0.045), and Group P1 and P2 do not exhibit a significant difference (p=0.848; 0.120). Conclusion: Propolis can significantly reduce the degree of interstitial fibrosis in the adenine-induced chronic kidney disease model compared to a control group.
Keywords
propolis; chronic kidney disease; animal model; adenine.
Cite This Article
Harimrti, M. F. Y., Susanto, J., Koendhori, E. B., Yuliawati, T. H., Abiati, N. A. (2024). Histopathology of Interstitial Fibrosis Degree Following Administration of East Java Nano Propolis in Adenine-Induced Chronic Kidney Disease Model (Rattus norvegicus). International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1460-1464, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.752-1460-1464.pdf
Volume 5 | Issue 6: Nov – Dec 2024
