The Administration of Omega-3 Therapy on C-Reactive Protein Levels, Neutrophil-To-Lymphocyte Ratio, Malondialdehyde, and Glasgow Outcome Scale Extended Scores in Patients with Moderate to Severe Head Injuries at Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar

I Gusti Ketut Agung Surya Kencana*, Joshua Sutikno, I Wayan Niryana, Tjokorda Gde Bagus Mahadewa 

Abstract

Head injury is one of the most common causes of death worldwide and also the most frequent cause of lifelong disability. Mechanically, several factors contribute to secondary injury, including neuroinflammation, excitotoxicity, mitochondrial dysfunction, oxidative stress, lipid peroxidation, axonal degeneration, and apoptotic cell death. The fundamental principle in managing head injury is to create an optimal environment for the injured brain tissue to recover and regain normal function. Omega-3, as an adjunct therapy for head injury patients, has anti-inflammatory effects and is effective as a strong anti-inflammatory factor. This study compares the administration of omega 3 as an adjunct therapy and standard therapy in terms of CRP, NLR, MDA levels, and GOS-E scores in patients with moderate and severe head injuries. Sample selection used a consecutive sampling technique, followed by simple randomization. In this study, normality testing was conducted using the Shapiro-Wilk test and median differences were analyzed using the Mann-Whitney test. The results show that omega-3 administration resulted in lower CRP (p < 0.001), NLR (p 0.015), and MDA (p 0.001) levels in patients with moderate to severe head injuries, but provided the same GOS-E scores as the control group (p 0.717).

Keywords

head injury; omega 3; CRP; NLR; MDA; GOS-E.

Cite This Article

Kencana, I. G. K. A. S., Sutikno, J. Niryana, I. W., Mahadewa, T. G. B. (2024). The Administration of Omega-3 Therapy on C-Reactive Protein Levels, Neutrophil-To-Lymphocyte Ratio, Malondialdehyde, and Glasgow Outcome Scale Extended Scores in Patients with Moderate to Severe Head Injuries at Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1543-1551, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.767-1543-1551.pdf

Volume 5 | Issue 6: Nov – Dec 2024