Analysis of APTT Values, Factor VIII Activity, Factor IX Activity, and Clinical Manifestations in Pediatric Hemophilia Patients at RSUD Dr. Soetomo Surabaya

Muhammad Sabilal Ma’ruf¹, Paulus Budiono Notopuro^2,3*, Mia Ratwita Andarsini^4,5, Yulia Nadar Indrasari⁶

Abstract

Background: Hemophilia is a blood clotting disorder caused by a deficiency of blood clotting factors, namely FVIII deficiency (Hemophilia A) and FIX deficiency (Hemophilia B). World epidemiological data shows that the prevalence rate of Hemophilia A is 85-90% and Hemophilia B is 10-15%. Objective: To analyze the correlations between Hemophilia factor activity with APTT values and clinical manifestations of pediatric Hemophilia patients at RSUD Dr Soetomo Surabaya. Methods: This study used a retrospective observational design. Subjects were pediatric hemophilia patients who met the inclusion criteria from total sampling data for the period January 2018-December 2022 from patient medical records. Results: It is known that the majority of pediatric Hemophilia patients in the age range of 2-10 years, as many as 50%. Descriptive statistical values were expressed in (mean ± SD), including APTT value (69 ± 25), FVIII activity (4.6 ± 5.9), and FIX activity (12 ± 15). The most clinical manifestation of bleeding was joint bleeding (hemarthrosis). There were 23 patients with Hemophilia A and 3 patients with Hemophilia B. There was no significant relationship between Hemophilia factor activity and APTT values using the Chi-Square Test statistical test. There was also no significant relationship between hemophilia factor activity and manifestations of hemophilia using the Kruskal-Wallis correlation test. Conclusion: The results of this study indicate that there are no correlations between Factor VIII activity and Factor IX activity with APTT values or with clinical manifestations that occur in patients.

Keywords

Hemophilia; APTT value; FVIII activity; FIX activity; hemarthrosis.

Cite This Article

Ma’ruf, M. S., Notopuro, P. B., Andarsini, M. R., Indrasari, Y. N. (2024). Analysis of APTT Values, Factor VIII Activity, Factor IX Activity, and Clinical Manifestations in Pediatric Hemophilia Patients at RSUD Dr. Soetomo Surabaya. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1705-1709, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.793-1705-1709.pdf

Volume 5 | Issue 6: Nov – Dec 2024