The Potency of Silver Nanoparticle and Flavonoid in Centella Asiatica Extract as Inhibitors of BRAF V600E Mutation in Melanoma: A Literature Review
Rania Zahra Regita1, Rendy Steven Pratama1, Sonya Marella Tiomaulan Situmorang1, Reny I’tishom3*
Abstract
Melanoma, one of the most aggressive skin cancers, is often driven by the BRAF V600E mutation, which promotes tumor growth and therapeutic resistance. This study investigates the potential of silver nanoparticles (AgNPs) and flavonoids from Centella asiatica extract as inhibitors of this mutation. AgNPs, known for their selective cytotoxicity and nanoparticle precision, disrupt cancer cell signaling pathways, inducing apoptosis and inhibiting proliferation. Flavonoids exhibit complementary anti-inflammatory, antioxidant, and cytotoxic properties, targeting the MAPK pathway and reducing oxidative stress. The research emphasizes the synergistic potential of these agents, which may enhance therapeutic outcomes while reducing systemic toxicity. A systematic literature review spanning 2010–2024 provides a comprehensive analysis of molecular mechanisms, computational findings, and experimental results. The integration of nanotechnology and natural compounds offers a groundbreaking strategy to address melanoma’s complexity and drug resistance. While promising, the findings highlight the need for further clinical trials to validate safety and efficacy. This innovative approach paves the way for targeted and personalized therapies in oncology.
Keywords
melanoma; BRAF V600E; silver nanoparticles; flavonoids; nanotechnology.
Cite This Article
Regita, R. Z., Pratama, R. S., Situmorang, S. M. T., I’tishom, R. (2024). The Potency of Silver Nanoparticle and Flavonoid in Centella Asiatica Extract as Inhibitors of BRAF V600E Mutation in Melanoma: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1715-1724, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.795-1715-1724.pdf
Volume 5 | Issue 6: Nov – Dec 2024
