Differences in the Levels of Inflammation and Infection in the Thyroid Surgery Area Between Groups With and Without Antibiotic Prophylaxis
Maria Sesilia Suzanna Sugiharto1*, Ni Gusti Ayu Agung Manik Yuniawaty Wetan2, I Wayan Sudarsa2
Abstract
Background: Surgical site infections (SSIs) are infectious complications associated with all surgical procedures, occurring within 30 days post-operation or up to 90 days. The prevalence of SSIs varies and comprehensive data collection on their incidence is lacking. This study aims to determine the difference in inflammation and thyroid surgical site infections between groups with and without prophylactic antibiotics. Methods: This research is a retrospective cohort study, where data will be obtained from secondary sources in medical records. The data collected includes age, gender, ASEPSIS scores, type of surgery, duration of surgery, length of hospital stay, incidence of inflammation, infection, type of antibiotic, and administration procedure. Descriptive statistical analysis, Chi-Square Test, independent t-test, and Mann-Whitney test were conducted using IBM SPSS version 26. Results: The results of the study showed the mean age to be over 50 years, with the majority being female. The ASEPSIS score for the antibiotic group had a mean of 11.15±8.31, while the non-antibiotic group had a mean of 11.92±6.10 (p=0.766). The median duration of surgery for both groups was 1 hour (ranging from 1 to 3 hours). The antibiotic used was Cefazolin, administered at a dose of 1 gram 30 minutes before surgery, followed by 1 gram every 8 hours for 24 hours post-operation intravenously. The incidence of inflammation had an OR of 3.44 (95% CI 0.52-22.43), p=0.185. The incidence of local infection had an OR of 1.65 (95% CI 0.22-11.99), p=0.619. Conclusions: This study concludes there is no difference in the levels of inflammation and thyroid surgical site infections between the groups receiving prophylactic antibiotics and those not receiving prophylactic antibiotics.
Keywords
antibiotics; surgical site infection; thyroid surgery; ASEPSIS score; inflammation level.
Cite This Article
Sugiharto, M. S. S., Wetan, N. G. A. A. M. Y., Sudarsa, I. W. (2025). Differences in the Levels of Inflammation and Infection in the Thyroid Surgery Area Between Groups With and Without Antibiotic Prophylaxis. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 1: Jan-Feb 2025, Pages 122-128, URL: https://www.ijscia.com/wp-content/uploads/2025/01/Volume6-Issue1-Jan-Feb-No.831-122-128.pdf
Volume 6 | Issue 1: Jan – Feb 2025
