Antimalarial Drug Resistance in Africa: Current Status and Future Prospects

Emmanuel U. Usoro, Mistura A. Akintola*, Mariam O. Buari, Nkechinyere C. Dike, Alexandra I. Owulu, Olutomiwa A. Omokore, Jennifer C. Ndu-Nwankwo, Comfort E. Oyedepo, Emuvoke A. Isire, Oluwagbemiga J. Bamidele, Nneoma U. Timothy, Ebike-enie K. Tantua, Chidinma R. Ndubueze, Elizabeth A. Nasamu, Chidera A. Okezie-Okoye, Boluwatife S. Atolagbe, Jesutoni S. Ademolake, Augustine Ayokunle Ogunleye, Uyiosa S. Odiase, Chinem Emordi, Toochukwu O.S. Uzohue, Ikechukwu Treasure C, Promise T. Okwor, Osagie W. Nosahoro, David O. Ekpakpale, John I. Akindipe, Jesugbejami A. Jimoh, and Ayebabomonyo B. Basuo

Abstract

Malaria remains a significant public health concern in Africa, with millions of cases reported annually. However, the effectiveness of antimalarial drugs, a cornerstone of malaria control efforts, is threatened by the emergence and spread of drug-resistant strains of the Plasmodium parasite. This article provides a comprehensive overview of the current status of antimalarial drug resistance in Africa and explores prospects for combatting this critical issue. In recent years, various regions across the continent have witnessed the rise of drug-resistant malaria strains, posing formidable challenges to malaria treatment and control programs. We delve into the underlying genetic and molecular mechanisms driving drug resistance, shedding light on the role of mutations and the evolutionary forces at play. Despite these challenges, ongoing research and global collaborations offer hope for the future. Combination therapies, innovative drug development, and vector control measures are discussed as strategies to mitigate drug resistance. We also explore the potential of genomics and molecular studies in understanding and countering resistance. However, significant barriers persist, including limited funding, resource disparities, and access to healthcare in remote areas. Socioeconomic factors further complicate the landscape of malaria control. In conclusion, this article underscores the urgency of addressing antimalarial drug resistance in Africa as a public health priority. By staying informed about the current status, supporting research initiatives, and promoting effective policies and interventions, we can strive for a future where malaria treatment remains effective and accessible to all, ultimately working toward the goal of malaria eradication on the African continent.

Keywords

Cite This Article

Usoro, E. U., Akintola, M. A., Buari, M. O., Dike, N. C., Owulu, A. I., Omokore, O. A., Ndu-Nwankwo, J. C., Oyedepo, C. E., Isire, E. A., Bamidele, O. J., Timothy, N. U., Tantua, E. K., Ndubueze, C. R., Nasamu, E. A., Okoye, C. A. O., Atolagbe, B. S., Ademolake, J. S., Ogunleye, A. A., Odiase, U. S., Emordi, C., Uzohue, T. O. S., Ikechukwu, T. C., Okwor, P. T., Nosahoro, O. W., Ekpakpale, D. O., Akindipe, J. I., Jimoh, J. A., Basuo, A. B. (2024). Antimalarial Drug Resistance in Africa: Current Status and Future Prospects. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 1: Jan-Feb 2024, Pages 120-130, URL: https://www.ijscia.com/wp-content/uploads/2024/02/Volume5-Issue1-Jan-Feb-No.561-120-130.pdf

Volume 5 | Issue 1: Jan-Feb 2024