Concordance of TI-RADS Scores with Thyroid Histopathology and Its Relationship with TSH, T3, and T4 Levels in Thyroid Nodule Patients at Prof dr. I.G.N.G Ngoerah General Hospital
Raissa Andi Soekrisno1, Made Widhi Asih1, Putu Patriawan1, I Wayan Gede Artawan Eka Putra2, Elysanti Dwi Martadiani1, Ni Nyoman Margiani1
Abstract
Background: Thyroid gland disorders are the second most common endocrine disorder worldwide after diabetes. Ultrasonography (USG) with TI-RADS scoring is an essential modality for assessing the malignancy risk of thyroid nodules, while Fine Needle Aspiration Biopsy (FNAB) is used to determine the histopathological characteristics of the nodules. This study aims to assess the correlation between TI-RADS scores and histopathological results and their relationship with thyroid hormone levels in patients with thyroid nodules. Method: This is an observational analytic study with a cross-sectional design. The study uses the results of TI-RADS score measurements, histopathological findings, and thyroid hormone levels in patients with thyroid nodules. These three variables were measured simultaneously at the time of diagnosis. The collected data were processed and presented in the form of frequency distribution tables. All data obtained were statistically analyzed using the SPSS 24.0 for Windows, including descriptive statistical analysis, conformity tests, mean difference tests, and MANCOVA tests. Result: The total number of subjects was 39. TI-RADS scores of 4-5 showed malignant histological features in 19 subjects (48.7%), while 16 out of 20 subjects with TI-RADS scores in the range of 1-3 showed benign histological features, with a Kappa value of 0.796 (strong level of agreement) and an agreement percentage of 89.74%; p<0.001. There was no statistically significant difference between the mean levels of TSH, FT4, and T3 based on histological findings, as the p-values obtained were greater than 0.05. Conclusion: There is a statistically significant correlation between TI-RADS scores and histopathological findings, but no statistically significant difference in the mean levels of TSH, FT4, and T3 based on either the TI-RADS score categories or histopathological findings in patients with thyroid nodules.
Keywords
TI-RADS score; thyroid nodules; histopathological; TSH; FT4; T3
Cite This Article
Soekrisno, R. A., Asih, M. W., Patriawan, P., Putra, I. W. G. A. E., Martadiani, E. D., Margiani, N. N. (2024). Concordance of TI-RADS Scores with Thyroid Histopathology and Its Relationship with TSH, T3, and T4 Levels in Thyroid Nodule Patients at Prof dr. I.G.N.G Ngoerah General Hospital. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 4: Jul-Aug 2024, Pages 844-851, URL: https://www.ijscia.com/wp-content/uploads/2024/08/Volume5-Issue4-Jul-Aug-No.656-844-851.pdf
Volume 5 | Issue 4: Jul-Aug 2024
