Correlation between Estrogen Receptor, Progesterone Receptor, and Ki-67 Expression Levels with Neoadjuvant AC-T Chemotherapy Response in Triple Positive Breast Cancer (TPBC) Patients after Modified Radical Mastectomy (MRM) at Prof. Dr. I.G.N.G. Ngoerah General Hospital
Ni Made Apriliani Saniti1*, Ida Bagus Made Suryawisesa2, I Wayan Sudarsa2
Abstract
Background: Triple Positive Breast Cancer (TPBC), a subtype of breast cancer expressing ER, PR, and HER-2, has unique biological characteristics that influence therapy response. Neoadjuvant AC-T chemotherapy is commonly used for TPBC; however, the correlation between ER, PR, and Ki-67 expression levels and therapy response remains unclear. TPBC has a lower pathological complete response (pCR) rate compared to other subtypes, but a low pCR does not always indicate a poor prognosis. This study aimed to evaluate the correlation between ER, PR, and Ki-67 expression levels and the response to neoadjuvant AC-T chemotherapy in TPBC patients to support more effective and safer treatment strategies. Methods: This analytical observational study used a cross-sectional design conducted at Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, from June 2022 to June 2023. The target population was TPBC patients who underwent neoadjuvant AC-T chemotherapy and MRM surgery. Samples were collected using consecutive sampling. Data were analyzed using descriptive statistics, ROC curve analysis to determine variable cut-off points, and Chi-Square tests to assess relationships between variables. Results: ROC analysis showed a cut-off point for ER at 17.5% (AUC 0.506, p=0.950), PR at 25% (AUC 0.521, p=0.815), and Ki-67 at 35% (AUC 0.465, p=0.700). Chi-square tests revealed no significant correlation between high expression of ER (p=0.717), PR (p=0.505), or Ki-67 (p=0.970) and chemotherapy response. Conclusions: ER, PR, and Ki-67 expression levels do not significantly correlate with the response to neoadjuvant AC-T chemotherapy in TPBC patients.
Keywords
triple positive breast cancer; neoadjuvant chemotherapy; AC-T; estrogen receptor expression; progesterone receptor expression; Ki-67; therapy response.
Cite This Article
Saniti, N. M. A., Suryawisesa, I. B. M., Sudarsa, I. W. (2024). Correlation between Estrogen Receptor, Progesterone Receptor, and Ki-67 Expression Levels with Neoadjuvant AC-T Chemotherapy Response in Triple Positive Breast Cancer (TPBC) Patients after Modified Radical Mastectomy (MRM) at Prof. Dr. I.G.N.G. Ngoerah General Hospital. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1788-1797, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.808-1788-1797.pdf
Volume 5 | Issue 6: Nov – Dec 2024
