Effect Essential Oils of Soursop Leaf (Annona muricata Linn)
on LDL and HDL in Male Rats Induced by Rifampicin

Muhammad Iqbal Maulana Bakrun*, Sri Fauziyah, and Dini Sri Damayanti

Abstract

Introduction: Rifampicin is among the drug that causes liver damage through an increased level of Reactive Oxygen Species (ROS). Liver damage that occurs will disrupt lipoprotein metabolism, resulting in an increase of LDL and a decrease of HDL. Terpenoid compounds contained in essential oils of Annona muricata Linn were thought to have antioxidant activity. The purpose of this study is to demonstrate the effect of essential oils from Annona muricata Linn on LDL and HDLserum level induced with rifampicin. Methods: This study was an experimental study with a control group post-test only design using 25 male rats which was divided into 5 groups. A negative control (KN) group was induced with corn oils and a positive control (KP) was induced with rifampicin + corn oils. Treatment group (P1, P2, and P3) were similar with KP but were added with essential oils with a dose of 1,5%, 3%, and 6%, respectively. This study was conducted for 6 weeks. At the end of study, the animals were sacrifice to examined LDL and HDL levels. Results were analysed using One Way ANOVA followed with a post hoc test using the Least Significant Difference (LSD). Result: LDL levels between KP vs KN were significantly different. However, HDL levels between KP vs KN were not. These findings may be influenced by rifampicin dose, duration of induction, corn oils use, and serum hemolysis. Treatment of essential oils can reduce LDL levels significantly but, it wasn’t significant for HDL levels. Terpenoid and steroid compounds acts as antioxidant and anti-inflammatory agents, and was able to inhibit the formation of free radicals, therefore minimizing liver damage. Variations of doses of essential oils in this study was not shown to have a different effect significantly. Conclusion: Essential oils of Annona muricata Linn can reduce LDL, but was not effective in increasing HDL levels in male rats induced with rifampicin.

Keywords

Rifampicin; Essential oils of Annona muricata Linn; LDL; HDL

Cite This Article

Bakrun, M. I. M., Fauziyah, S., Damayanti, D. S. (2023).  Effect Essential Oils of Soursop Leaf (Annona muricata Linn) on LDL and HDL in Male Rats Induced by Rifampicin. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 4: Jul-Aug 2023, Pages 563-567, URL: https://www.ijscia.com/wp-content/uploads/2023/07/Volume4-Issue4-Jul-Aug-No.470-563-567.pdf

Volume 4 | Issue 4: Jul-Aug 2023