Effect of Sorghum (Sorghum Bicolor L.) Ethanol Extract in Preventing Significant Increased Blood Glucose Levels, Interleukin-6 (IL-6) and Malondialdehyde (MDA) in White Rats (Rattus Norvegicus) Wistar Male Strain with Nicotinamid-Streptozotocin Induced Diabetes Mellitus

Ratna Tri Permata¹, Agus Eka Darwinata², Made Ratna Saraswati³, Gde Ngurah Indraguna Pinatih⁴, I Wayan Weta⁴, and I Wayan Putu Sutirta Yasa⁵

Abstract

Introduction: Atherosclerosis is the most common cause of mortality and morbidity in the world. Various efforts to prevent atherosclerosis, one of which is squalene supplementation. This review will discuss the role of squalene in preventing atherosclerosis through its effect on reducing LDL levels. Discussion: Squalene can prevent the formation of atherosclerotic plaques through the mechanism of suppressing the expression of the CD36 ox-LDL receptor on the surface of monocytes and macrophages, thereby reducing the uptake of ox-LDL without causing cytotoxicity. In addition, squalene also provides an antiproliferative effect on macrophages and monocytes resulting in a decrease in the formation of atherosclerosis. Conclusion: In theory, administration of Squalene can prevent atherosclerosis by reducing total cholesterol, LDL, triglycerides, and increasing HDL levels.

Keywords

Atherosclerosis; LDL; squalene

Cite This Article

Permata, R. T., Darwinata, A. E., Saraswati, M. R., Pinatih, G. N. I., Weta, I. W., Yasa, I. W. P. S. (2023). Effect of Sorghum (Sorghum Bicolor L.) Ethanol Extract in Preventing Significant Increased Blood Glucose Levels, Interleukin-6 (IL-6) and Malondialdehyde (MDA) in White Rats (Rattus Norvegicus) Wistar Male Strain with Nicotinamid-Streptozotocin Induced Diabetes Mellitus. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 4: Jul-Aug 2023, Pages 571-575, URL: https://www.ijscia.com/wp-content/uploads/2023/07/Volume4-Issue4-Jul-Aug-No.472-571-575.pdf

Volume 4 | Issue 4: Jul-Aug 2023