Effectiveness of Diabetogenic Agent Streptozotocin in Inducing Diabetes Mellitus in Experimental Animals: A Literature Review
Mohammad Yusuf Maulana Habibi1, Nurmawati Fatimah2*
Abstract
Background: Diabetes mellitus is one of the serious diseases due to its chronicity which can cause complications to various organs. Various animal studies on complications of Diabetes mellitus are needed. Research on animal studies of Diabetes mellitus is very diverse in terms of the studies studied and the variants of diabetogenic agents that induce Diabetes mellitus. Objective: This literature review compares and reviews several studies related to the use of streptozotocin as a diabetogenic agent that induces diabetes mellitus in experimental animals and highlights the effectiveness of streptozotocin in causing the incidence of diabetes mellitus in experimental animals. Method: The method that the researcher used in this study is a non-systematic review that uses database sources from journal publications in ScienceDirect, PubMed, and Google Scholar. Result: Streptozotocin is able to effectively cause hyperglycemia and induce diabetes mellitus in experimental animals. In previous studies, it was found that intraperitoneal injection of low-dose streptozotocin is able to maintain a state of hyperglycemia for a long time, making it easier to observe complications of diabetes.
Keywords
streptozotocin; diabetes mellitus; experimental animal.
Cite This Article
Habibi, M. Y. M., Fatimah, N. (2024). Effectiveness of Diabetogenic Agent Streptozotocin in Inducing Diabetes Mellitus in Experimental Animals: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1635-1638, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.782-1635-1638.pdf
Volume 5 | Issue 6: Nov – Dec 2024
