Effects Combination of Purple Sweet Potato Tub Ethanol Extract (Ipomoea batatas L.) And Atorvastatin on Levels Low-Density Lipoprotein and Intima-Media Thickness of The Aorta in Male Wistar Rats (Rattus norvegicus) Exposed to A High Fat Diet
Putu Dian Pratita Lestari*, Anak Agung Ayu Dwi Adelia Yasmin, and I Nyoman Wiryawan
Abstract
Background: Coronary heart disease (CHD) is still the leading cause of morbidity and mortality. Preventive measures are very important-density lipoprotein (LDL) and aortic intimal-media thickness (IMT) are associated with cardiovascular events. Statins are not optimal even though their efficacy has been proven. Purple sweet potato extract has been shown to have the potential to lower LDL and have antioxidant effects. Objective: Assessing the effect of the combination of ethanol extract of purple sweet potato tubers and atorvastatin on LDL levels and aortic IMT in male Wistar rats exposed to a high-fat diet. Method: An experimental study with a posttest-only posttest control group design. The total sample was 25 mice, all receiving a high-fat diet. Rats were divided into control groups and 3 treatments, namely P(1) atorvastatin 1.4 mg/day, P(2) ethanol extract of purple sweet potato tubers 3 ml/day, P(3) atorvastatin 1.4 mg/day + ethanol extract purple sweet potato tubers 3 ml/day. At week 9, LDL levels and aortic IMT were checked. Results: There is a significant difference in LDL between the treatment and control groups. The combination group had the lowest mean LDL compared to the other groups P1:20.10±1.03μg/ml; CI95%22.81–23.77μg/ml; p<0.001; P2: 23.29±0.57μg/ml CI95%22.81–23.77μg/ml; p<0.001; P3: 15.93±0.76μg/ml; 95%CI15.30-6.57μg/ml; p<0.001). The ability of single therapy of atorvastatin and purple sweet potato extract was not significantly different in reducing the mean aortic IMT P1: 46.39±3.81μm; CI95% 43.20–39.58μm; p <0.001; P2: 49.93±4.3μm; CI 95% 46.33–53.53μm, p<0.001 The combination of atorvastatin and ethanol extract of purple sweet potato tubers can reduce the mean aortic IMT compared to the single therapy group (P3: 41.22±1.99μm; CI95% 39.55–42.88μm; p<0.001). Conclusion: The combination of atorvastatin 1.4 mg/day and ethanol extract of purple sweet potato tubers 3 ml/day significantly reduced LDL levels and aortic IMT compared to the control group and single therapy.
Keywords
a combination of atorvastatin and ethanol extract of purple sweet potato tubers; high-fat diet; LDL cholesterol levels; aortic IMT
Cite This Article
Lestari, P. D. P., Yasmin, A. A. A. D. A., Wiryawan, I. N. (2024). Effects Combination of Purple Sweet Potato Tub Ethanol Extract (Ipomoea batatas L.) And Atorvastatin on Levels Low-Density Lipoprotein and Intima-Media Thickness of The Aorta in Male Wistar Rats (Rattus norvegicus) Exposed to A High Fat Diet. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 3: May-Jun 2024, Pages 476-485, URL: https://www.ijscia.com/wp-content/uploads/2024/05/Volume5-Issue3-May-Jun-No.608-476-485.pdf
Volume 5 | Issue 3: May-Jun 2024
