Effect of Probiotic on Repair of Ethanol-induced Gastric Mucosal Erosion in Wistar Rats

Dedy Setiawan*, Alpha Fardah Attiyah, Reza Gunadi Ranuh, Andy Dharma, Subijanto Marto Sudarmo

Abstract

Background: Probiotics can increase mucus secretion as a mechanism to improve barrier function and pathogen exclusion. Several Lactobacillus species can increase mucin expression in human intestinal cells. Lactobacillus Plantarum IS-10506 is a probiotic native to Indonesia derived from curd, fermented milk from Sumatra. Research with Lactobacillus Plantarum IS-10506 showed a protective effect as well as a therapeutic effect on intestinal mucosal damage to the ileum. Objective: Analyzing the effect of probiotic Lactobacillus Plantarum IS-10506 on the acceleration of ethanol-induced gastric mucosal erosion regeneration. Method: Experimental research used 48 rats that were fasted and divided into 3 groups those are K1 group control group, group K2 which was treated with ethanol 43%, and group K3 which was treated with ethanol and probiotic Lactobacillus Plantarum IS-10506. Each group was divided into 4 subgroups based on the day of the sacrifice those are days 1, 3, 5, and 7.  The treatment of the test animals is done in 7 days. Epithelial defect was measured by using histopathologic scoring by Roger’s Results: The score of Epithelial defect Group K2 was significantly different compared to group K1 (p=0.036), and K3 (p=0.007). The gastric mucosal repair was completed in day 7 in the probiotic group. Conclusion: Probiotic Lactobacillus Plantarum IS-10506 accelerate mucosal repair in etanol induced gastric mucosal injury

Keywords

Lactobacillus Plantarum IS-10506; ethanol; gastric mucosal repair

Cite This Article

Setiawan, D., Attiyah, A. F. A., Ranuh, R. G., Dharma, A., Sudarmo, S. M. (2022). Effect of Probiotic on Repair of Ethanol-induced Gastric Mucosal Erosion in Wistar Rats. International Journal of Scientific Advances (IJSCIA), Volume 3| Issue 3: May-Jun 2022, Pages 363-367, URL: https://www.ijscia.com/wp-content/uploads/2022/07/Volume3-Issue3-May-Jun-No.269-363-367.pdf

Volume 3 | Issue 3: May-Jun 2022