Fungal Colonization in Urinary Catheters: Pathophysiology and Clinical Implication
Sintia Pratiwi Subianto1, Pepy Dwi Endraswari2*
Abstract
Fungal colonization in urinary catheters is an emerging concern in clinical practice, particularly due to its association with catheter-associated urinary tract infections (CAUTIs). This literature review explores the pathophysiology of fungal colonization, with a focus on Candida species, particularly Candida albicans, which has become a significant uropathogen in patients with indwelling catheters. The review highlights how the catheter environment, characterized by mechanical trauma and inflammation, promotes fungal adherence and biofilm formation through mechanisms involving host proteins such as fibrinogen. The clinical implications of fungal colonization are profound, as it increases the risk of severe infections, particularly in immunocompromised patients. This review discusses various risk factors contributing to fungal colonization, including prolonged catheter use, underlying medical conditions such as diabetes, and the impact of broad-spectrum antibiotics on the normal flora. Furthermore, it addresses the diagnostic challenges posed by fungal infections, which are often overlooked due to a predominant focus on bacterial pathogens. To mitigate these risks, the review proposes several prevention and management strategies, including minimizing catheter use, employing aseptic techniques during insertion, and considering antifungal-coated catheters. By synthesizing current research findings, this review underscores the need for heightened awareness and improved management practices to address the growing challenge of fungal colonization in urinary catheters and its associated complications.
Keywords
urinary catheterization; fungal colonization; candida species; catheter-associated urinary tract infections.
Cite This Article
Subianto, S. P., Endraswari, P. D. (2024). Fungal Colonization in Urinary Catheters: Pathophysiology and Clinical Implication. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1771-1776, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.805-1771-1776.pdf
Volume 5 | Issue 6: Nov – Dec 2024
