High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles
Putu Shinta Widari Tirka, I Gusti Ayu Agung Praharsini*, I Gusti Ayu Agung Dwi Karmila, Luh Made Mas Rusyati, Nyoman Suryawati, and Ni Luh Putu Ratih Vibriyantikarna
Abstract
Background: Matrix metalloproteinase-1 was chosen in this study because it is a subgroup of MMPs that play an essential role in the photoaging process of collagenases with degradation of collagen types 1 and 2 as a result of direct UVA and UVB exposure with significantly increased regulation of these exposures compared to other types of MMPs. The purpose of this study is to prove a positive correlation between high MMP-1 serum levels and the severity of facial wrinkles in photoaging subjects. Methods: Observational analytic study using a cross-sectional approach with comparative analysis aims to determine differences in the severity of facial wrinkles in patients experiencing Photoaging based on MMP-1 levels. Subjective clinical observation of wrinkles with Glogau score and objective use of the A-One-Facial Analyzer tool. Analyzing using SPSS 26. Results: 51 subjects were divided into two groups, 30 photoaging, and 21 non-photoaging. The results of the A-One-Facial Analyzer Photoaging group were 5.30 (4.70-6.50) and without Photoaging were 4.80 (4-5). MMP-1 serum levels in the Photoaging group median of 17.69 (9.78-84.07) pg./ml and non-photoaging group 11.56 (8.07-19.62) pg/ml (p <0.001). Spearman Rho test between MMP-1 levels and wrinkles on the face obtained a moderate positive relationship with a correlation coefficient value (r) of 0, 5 and p-value <0.001. The result of the coefficient β was 41,5%, R-square 48%, and it was statistically significant with p = 0.002. Conclusion: High serum levels of matrix metalloproteinase -1 (MMP-1) have a positive correlation with the severity of facial skin wrinkles that experience Photoaging.
Keywords
facial wrinkles; matrix metalloproteinase -1 (MMP-1) serum levels; aging; young age; Photoaging
Cite This Article
Tirka, P. S. W., Praharsini, I. G. A. A., Karmila, I. G. A. A. D., Rusyati, L. M. M., Suryawati, N., Vibriyantikarna, N. L. P. R. (2023). High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 1: Jan-Feb 2023, Pages 122-129, URL: https://www.ijscia.com/wp-content/uploads/2023/02/Volume4-Issue1-Jan-Feb-No.402-122-129.pdf
Volume 4 | Issue 1: Jan-Feb 2023
