Immunohistochemistry Assay for Differentiating Liposarcoma and Its Mimickers
Fira Soraya & Willy Sandhika*
Abstract
Introduction: Soft tissue tumors account for 1 – 1.5% of all cancer, which is the tenth most common cancer in referral oncology hospitals in Indonesia. Liposarcomas are a group of histologically diverse lesions, accounting for 12.8% – 20% of all soft tissue malignancies. Some soft tissue tumors may show similar histological appearance, making differentiating mesenchymal neoplasms a difficult challenge. Immunohistochemical examination is an advanced examination to refine and determine the diagnosis that cannot be established based on histopathological examination only. Methods: This study was an observational descriptive study with a retrospective approach. The data of patients with liposarcoma was obtained from immunohistochemistry examination results in Dr. Soetomo General Academic Hospital during 2020 – 2022 period, which includes the histopathology result. All cases were classified based on WHO. We considered only patients with immunohistochemistry examination proven diagnosis who underwent surgery or biopsy in the same institution. Results: The total number of liposarcoma cases was 20, with most patients were male (90%) and age group 40 – 49 years old (30%). The most common location was the abdominal region (55%), including intra-abdominal, mesentery, and retroperitoneal. The most common subtype was dedifferentiated liposarcoma with 10 cases (50%). Conclusions: Immunohistochemistry examination in malignant adipocytic tumors aims to confirm the diagnosis, with the most common subtype being dedifferentiated liposarcoma. It is necessary to consider the morphology in H&E staining together with the immunohistochemistry profile as well as all clinical and radiology information to establish the most relevant diagnosis.
Keywords
tumor; neoplasm; soft tissue tumors; cancer; liposarcoma
Cite This Article
Soraya, F., Sandhika, W. (2024). Immunohistochemistry Assay for Differentiating Liposarcoma and Its Mimickers. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 3: May-Jun 2024, Pages 573-578, URL: https://www.ijscia.com/wp-content/uploads/2024/06/Volume5-Issue3-May-Jun-No.618-573-578.pdf
Volume 5 | Issue 3: May-Jun 2024
