Molecular Biomarkers of NSAID-induced Gastritis
Wisik Candra Padmasari 1 , Willy Sandhika 1,2*
Abstract
Nonsteroidal anti-inflammation drug (NSAID) has been commonly used by people to treat myalgia and arthritis. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) can cause chronic gastritis due to its topical and systemic effects. The topical effects of NSAID comprise cytotoxic and apoptotic effects on gastric mucosa which involve many apoptosis biomarkers while systemic effects are associated with cyclooxygenase (cox) inhibition in the reduction of prostaglandins production that plays a role in gastric mucosa’s protectors. Apoptosis biomarkers that are involved in NSAID-induced gastritis comprise tumor necrosis factor-alpha (TNF-α) as well as cytochrome-c and SMAC which act as apoptosis inducers via extrinsic and intrinsic pathways respectively, caspase-8, caspase-9, caspase-3 in apoptosis pathway, Apoptosis Inducing Factor (AIF), longevity of apoptotic inhibitor proteins and NF-kB activity, resulting in apoptosis and cytotoxic effect to develop gastritis. This review will help us to understand the safety of NSAID drugs and to find effective treatments to regulate its mediators and not just suppress gastric acid secretion.
Keywords
chronic disease; gastritis; drug safety; nonsteroidal anti-inflammation drug; tumor necrosis factor.
Cite This Article
Padmasari, W. C., Sandhika, W. (2025). Molecular Biomarkers of NSAID-induced Gastritis. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 1: Jan-Feb 2025, Pages 155-164 URL: https://www.ijscia.com/wp-content/uploads/2025/01/Volume6-Issue1-Jan-Feb-No.836-155-164.pdf
Volume 6 | Issue 1: Jan – Feb 2025
