Profile of Neuropsychiatric Manifestations in Pediatric Systemic Lupus Erythematosus (SLE) Patients
Kezia Angeline Wijaya1, Zahrah Hikmah2, Mudjiani Basuki3
Abstract
Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease involving multiple systems and is associated with significant morbidity and mortality. SLE can cause serious organ damage, one of which is the nervous system, known as neuropsychiatric SLE (NPSLE). Neuropsychiatric manifestations affect nearly half of SLE patients; the impact is very large on the severity of the disease, quality of life, and the prognosis of SLE. The symptoms vary from being diffuse and mild to causing acute life-threatening events. Objective: This study aimed to analyze the profile of neuropsychiatric manifestations of pediatric patients with SLE at Dr. Soetomo General Academic Hospital Surabaya for the period of January 2023–June 2024. Methods: This is a retrospective observational descriptive study design based on secondary data from Dr. Soetomo General Academic Hospital Surabaya. The study objects were 38 pediatric SLE patients whose ages were below 18 years old. The variables of this study were age, sex, and neuropsychiatric manifestation. Result: From 38 pediatric SLE patients, there were 18 patients (47.4%) with neuropsychiatric manifestations. From those 18 patients, the most common neuropsychiatric manifestations were cognitive dysfunction (38.9%), headache (33.3%), and mood disorders (27.9%).
Keywords
systemic lupus erythematosus (SLE); pediatric; neuropsychiatric manifestations; lupus; neuropsychiatric systemic lupus erythematosus (NPSLE).
Cite This Article
Wijaya, K. A., Hikmah, Z., Basuki, M. (2024). Profile of Neuropsychiatric Manifestations in Pediatric Systemic Lupus Erythematosus (SLE) Patients. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1552-1557, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.768-1552-1557.pdf
Volume 5 | Issue 6: Nov – Dec 2024
