Ratio of Estimated Right Atrial Pressure with Pulmonary Capillary Wedge Pressure and Estimated Plasma Volume Status as Predictor of Major Adverse Cardiovascular Event During Hospitalization in Patients with Acute Heart Failure
Benediktus Bosman Ariesta*, A.A.A. Dwi Adelia Yasmin, and Ida Bagus Rangga Wibhuti
Abstract
Background: Major cardiovascular events (MACE) in acute heart failure (AHF) are relatively high. The role of Estimated Right Atrial Pressure to Pulmonary Capillary Wedge Pressure (ERAP/EPCWP) and Estimated Plasma Volume Status (EPVS) as predictors of MACE during AHF hospitalization needs to be clarified. Objective: To determine whether ERAP/EPCWP and EPVS are predictors of MACE during AHF hospitalization. Methods: This prospective cohort study of AHF patients from February to April 2024. The independent variables are ERAP/EPCWP and EPVS. MACE outcomes consist of all-cause mortality, cardiogenic shock, malignant arrhythmias, and the incidence of renal replacement therapy. Samples were selected by consecutive sampling that met the inclusion and exclusion criteria and then observed during hospitalization. Results: A total of 62 AHF patients were included in the study. The MACE occurred in 45.2% of cases. The ERAP/EPCPWP cut-off point based on the ROC curve was ≥0.535 (95% CI 0.767-0.961; p<0.001; AUC 0.864). The EPVS cut-off point was ≥4.895 (95% CI 0.656-0.89; p<0.001; AUC 0.773). The cumulative survival on the fifth day in the ERAP/EPCWP ≥0.535 and <0.535 groups was 19.6 and 86.5%, respectively (p<0.001), while in the EPVS ≥0.4895 and <0.4895 groups, 29.6% and 71.7% respectively (p<0.001). The ERAP/EPCWP ≥0.535 and EPVS ≥0.4895 each were independent predictors of MACE during hospitalization (adjusted HR ERAP/EPCWP 8.89; 95% CI 2.936-26.972; p<0.001 and adjusted HR EPVS 5.046; 95% CI 1.893 -13.449; p<0.001). Conclusion: The ERAP/EPCWP and EPVS are independent predictors of MACE during AHF hospitalization.
Keywords
ERAP/EPCWP; EPVS; acute heart failure; major cardiovascular events
Cite This Article
Ariesta, B. B., Yasmin, A.A.A. D. A., Wibhuti, I. B. R. (2024). Ratio of Estimated Right Atrial Pressure with Pulmonary Capillary Wedge Pressure and Estimated Plasma Volume Status as Predictor of Major Adverse Cardiovascular Event During Hospitalization in Patients with Acute Heart Failure. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 3: May-Jun 2024, Pages 494-503, URL: https://www.ijscia.com/wp-content/uploads/2024/05/Volume5-Issue3-May-Jun-No.610-494-503.pdf
Volume 5 | Issue 3: May-Jun 2024
