Relationship Between Clinical, Laboratory, and Radiological Symptoms with The Incidence of Active Pulmonary Tuberculosis in People with Type 2 Diabetes Mellitus
Margret Prayerny Kalasina Waitau1, Ni Luh Putu Eka Arisanti1*, Wira Gotera2, Ida Ayu Jasminarti Dwi Kusumawardani1, Ni Wayan Candrawati1, I Gusti Ngurah Bagus Artana3, Ida Bagus Ngurah Rai1
Abstract
Background: Type 2 diabetes mellitus (DM) is an independent risk factor for TB that increases the risk of morbidity and mortality. Method: This research is an observational analytical study using a cross-sectional design, which was conducted at Prof. Ngoerah General Hospital Denpasar, Bali over a 3-year period (January 2019-March 2023). Results: There were 106 samples that met the inclusion criteria consisting of 53 DM-TB subjects and 53 non-TB DM subjects. The results of bivariate analysis showed that there was a significant relationship between cough (PR= 13.67, p= <0.001), weight loss (PR= 3.18, p= <0.001), night sweats (PR= 2.02, p= 0.001), NLR³ 4.76 (PR= 2.53, p= <0.001), MLR³ 0.44 (PR= 2.58, p= <0.001), anemia (PR= 2.26, p= <0.001), uncontrolled HbA1c (PR= 1.65, p= 0.042) with the incidence of active pulmonary TB in people with type 2 DM. The results of multivariate analysis showed that the independent variables consisted of cough (OR= 91.90, p= < 0.001), weight loss (OR= 11.32, p= < 0.001), night sweats (OR= 24.27, p = 0.008), atypical lesions (OR= 2183.74 p= 0.002), typical lesions (OR= 12273.19, p=0.033) affect the incidence of active pulmonary TB in people with type 2 DM. TB scoring results were obtained in people with type 2 DM if suggestive of pulmonary TB if major criteria by adding one or more minor criteria and non-suggestive TB if one or more minor criteria without major criteria. Conclusion: There is a relationship between coughing, night sweats, weight loss, increased NLR, MLR, HbA1c, anemia, typical lesions and atypical lesions with the incidence of active pulmonary TB in people with type 2 DM. TB scoring results were obtained in people with type 2 DM if suggestive of pulmonary TB if major criteria by adding one or more minor criteria and non-suggestive TB if one or more minor criteria without major criteria.
Keywords
DM-TB; clinical symptoms; NLR; MLR; Anemia; HbA1c; Typical lesions; Atypical lesions.
Cite This Article
Waitau, M. P. K., Arisanti, N. L. P. E., Gotera, W., Kusumawardani, I. A. J. D., Candrawati, N. W., Artana, I. G. N. B., Rai, I. B. N. (2023). Relationship Between Clinical, Laboratory, and Radiological Symptoms with The Incidence of Active Pulmonary Tuberculosis in People with Type 2 Diabetes Mellitus. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 6: Nov-Dec 2023, Pages 811-826, URL: https://www.ijscia.com/wp-content/uploads/2023/11/Volume4-Issue6-Nov-Dec-No.514-811-826.pdf
Volume 4 | Issue 6: Nov-Dec 2023
