Relationship Between Neutrophil-To-Lymphocyte Ratio, Muscle Mass and Fat Mass Percentage with Quality of Life in Non-Small Cell Lung Cancer

Ni Nyoman Widyastuti Lestari^1*, Ida Ayu Jasminarti Dwi Kusumawardani¹, Agustinus I Wayan Harimawan², Ni Wayan Candrawati¹, I Gusti Ngurah Bagus Artana¹, Ni Luh Putu Eka Arisanti¹, and Ida Bagus Ngurah Rai¹

Abstract

Background: Cachexia is a challenging condition characterized by the loss of muscle and/or fat mass, often seen in cancer patients. Assessing the impact of inflammatory markers like Neutrophil-to-Lymphocyte Ratio (NLR) along with muscle and fat mass on quality of life can provide valuable insights for improving the management and treatment of patients with non-small cell lung cancer. Method: This was an analytical observational analytic study conducted using a cross-sectional design in Bali from August to September 2023. Univariate analysis presents data in the form of frequency, median, mean and standard deviation. Bivariate analysis was carried out using Chi-Square and multivariate analysis using multiple logistic regression. Result: The total number of research subjects who met the requirements were 93 patients. The analysis showed a significant relationship between NLR and muscle mass (CI: 95%, OR: 2.373, p-value = 0.042) while there was no relationship between NLR and fat mass percentage (CI: 95%, OR: 1.568, p value = 0.382). Variables NLR (CI: 95%, adjOR: 0.217, p value=0.032), muscle mass (CI: 95%, adjOR: 12.207, p value=0.002), fat mass (CI: 95%, adjOR: 9.128, p-value =0.020) is significantly related to quality of life. Conclusion:  NLR levels, muscle mass, and fat mass percentage have a significant relationship with the quality of life of NSCLC patients. The NLR was related to muscle mass, while there is no relationship between NLR and the percentage of muscle mass.

Keywords

muscle mass, fat mass percentage; quality of life; Neutrophil-to-Lymphocyte Ratio (NLR); Non-Small Cell Lung Cancer (NSCLC)

Cite This Article

Lestari, N. N. W., Kusumawardani, I. A. J. D., Harimawan, A. I. W., Candrawati, N. W., Artana, I. G. N. B., Arisanti, N. L. E., Rai, I. B. N. (2024). Relationship Between Neutrophil-To-Lymphocyte Ratio, Muscle Mass and Fat Mass Percentage with Quality of Life in Non-Small Cell Lung Cancer. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 2: Mar-Apr 2024, Pages 347-353, URL: https://www.ijscia.com/wp-content/uploads/2024/04/Volume5-Issue2-Mar-Apr-No.593-347-353.pdf

Volume 5 | Issue 2: Mar-Apr 2024