SARS-CoV-2 Variants and Clinical Implications: A Review Article
Daniel Zaputra1* & I Made Susila Utama2
Abstract
Introduction: Since being declared a global pandemic on March 11 2020 by the World Health Organization (WHO), the SARS-CoV-2 virus has caused more than 6.7 million global deaths as of January 2023. This literature review is to review the clinical implications of the SARS-COV-2 virus variant. Discussion: According to WHO, there are five SARS-CoV-2 VOCs have been detected since the start of the pandemic: alpha, beta, gamma, delta, and omicron. SARS-CoV-2 is an RNA virus that, like other RNA viruses, is susceptible to genetic evolution when adapting to a human host, resulting in changes over time and the production of numerous variants with distinct characteristics from the initial strain. Viruses originating from the same lineage may contain different subsets of mutations so that they are classified as different variants. Variants are characterized by their degree of transmissibility, severity of disease, and ability to evade the humoral immune system. Conclusion: SARS-CoV-2 variants are associated with increased transmission and infection capabilities of the virus through a mechanism based on mutations in the viral protein structure.
Keywords
SARS-CoV-2; pandemic; virus
Cite This Article
Zaputra, D., Utama, I. M. S. (2024). SARS-CoV-2 Variants and Clinical Implications: A Review Article. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 2: Mar-Apr 2024, Pages 271-276, URL: https://www.ijscia.com/wp-content/uploads/2024/03/Volume5-Issue2-Mar-Apr-No.581-271-276.pdf
Volume 5 | Issue 2: Mar-Apr 2024
