Osteogenesis Imperfecta: An Overview Rahma Ira Mustikasari1*, Nur Rochmah1, Muhammad Faizi1, Qurrota Ayuni Novia Putri2 Abstract Osteogenesis Imperfecta (OI) or commonly referred to as brittle bone disease is a congenital connective tissue formation disorder characterized by bone fragility, osteopenia, skin disorders, blue sclera, dentinogenesis imperfecta (DI), and hearing loss. The