High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles Putu Shinta Widari Tirka, I Gusti Ayu Agung Praharsini*, I Gusti Ayu Agung Dwi Karmila, Luh Made Mas Rusyati, Nyoman Suryawati, and Ni Luh Putu Ratih Vibriyantikarna Abstract Background: Matrix metalloproteinase-1 was chosen in