The Potency of Silver Nanoparticle and Flavonoid in Centella Asiatica Extract as Inhibitors of BRAF V600E Mutation in Melanoma: A Literature Review Rania Zahra Regita1, Rendy Steven Pratama1, Sonya Marella Tiomaulan Situmorang1, Reny I’tishom3* Abstract Melanoma, one of the most aggressive skin cancers, is often driven by the BRAF V600E