Metformin and Insulin: An Effective Therapeutic Combination for Overweight and Obese Type 1 Diabetes Patients? Adrian Azka Ghafar1, Maftuchah Rochmanti2*, Hermina Novida3, Ahmad Ikhwanuddin Natsir4 Abstract Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency due to the destruction of pancreatic beta cells. Patients with T1D