The Correlation Between Frequency of Transfusion and Alloimmunization in Transfusion-Dependent Thalassemia Patients

Aimmatul Yumna Nihayatul Wafa¹, Betty Agustina Tambunan^2*and Mia Ratwita Andarsini³

Abstract

Thalassemia is a red blood cell disorder caused by impaired synthesis of hemoglobin and is genetically inherited. Based on the need for transfusion, thalassemia is divided into transfusion-dependent thalassemia and non-transfusion-dependent thalassemia. Transfusion-dependent thalassemia patients require life-long red blood transfusions. Transfusions that are carried out will cause complications reactions to the body such as immune reactions, i.e. Alloimmunization. Alloimmunization remains a major problem in transfusion dependent thalassemia patients. Aims to determine the relationship between the frequency of transfusions and the incidence of alloimmunization in transfusion-dependent thalassemia patients. This research is an observational analytic study with a retrospective approach using secondary data in the form of medical records at the Pediatric Hematology Oncology Installation, Blood Transfusion Installation, and Central Medical Records at RSUD Dr. Soetomo 2019–2020. This study used 193 research samples, 165 patients (85.5%) did not experience alloimmunization and alloimmunization was found in 28 patients (14.5%). In the female group, 21 of 99 (21.2%) patients and in the male group 7 of 94 (7.4%) patients who had alloimmunization. The distribution of transfusion-dependent thalassemia patients get a transfusion frequency of 1–10 times (35.7%) before had alloimmunization. The relationship between the frequency of transfusions and the incidence of alloimmunization has p value = 0.65 (>0.05). There is no significant correlation between the frequency of transfusions and the incidence of alloimmunization in transfusion-dependent thalassemia patients.

Keywords

alloimmunization; thalassemia; transfusion

Cite This Article

Wafa, A. Y. N., Tambunan, B. A., Andarsini, M. R. (2023). The Correlation Between Frequency of Transfusion and Alloimmunization in Transfusion-Dependent Thalassemia Patients. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 1: Jan-Feb 2023, Pages 93-96, URL: https://www.ijscia.com/wp-content/uploads/2023/02/Volume4-Issue1-Jan-Feb-No.397-93-96.pdf

Volume 4 | Issue 1: Jan-Feb 2023