The Effect of HIV on the Heart and HAART on the Heart

Ohikhuare Okun^1*, Pekyi-Boateng Prince Kwabla², Oboseh John Ogedegbe³, Udegbe Daniel Chidiebere⁴, Blankson George Akyea⁵, Nnekachi Prayer Nnokam⁶, Oguntimehin Babatunde Augustine⁷, Johnson Ayodeji David⁸, Mohamed Abdirahman Abdi⁹, Agyemang Ohene Poku¹⁰, Igbinonwanhia Osahon Rex¹¹, Samuelson Osifo¹², Damkor Iember Joy¹³, Mba Nkiruka Ikpo¹¹, and Kengne Sob Carelle Vanessa²

Abstract

HIV/AIDS is a disease characterized by immune dysfunction with superimposed severe opportunistic liability. The past few years has seen a significant rise to 75% of HIV patients compliant on ART. Delving into specific complications reveal significant associations between HIV and HAART in the heart. The purpose of this article is to throw more light on the key role players in cardiac dysfunction among HIV patients on HAART. In this article, we discuss the effects of HIV-associated chronic inflammation, immune dysfunction, high-risk medications, and their effects on the cardiovascular, and metabolic systems which further hastens the progression of cardiac dysfunction in individuals. Complications such as heart failure, coronary artery disease, pericardial effusion, and pulmonary hypertension are also discussed to appreciate the pathophysiology and outcomes. We believe that if more studies into cardiac complications of HIV patients on HAART are conducted, many patients will benefit from the evidenced-based outcomes which will influence clinical decision-making. 

Keywords

HIV/AIDS; immune dysfunction; HAART; heart

Cite This Article

Okun, O., Prince Kwabla, P. B., Ogedegbe, O. J., Chidiebere, U. D., Akyea, B. G., Nnokam, N. P., Augustine, O. B., David, J. A., Abdi, M. A., Poku, A. O., Rex, I. O., Osifo, S., Joy, D. I., Ikpo, M. N., Vanessa, K. S. C. (2023). The Effect of HIV on the Heart and HAART on the Heart. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 4: Jul-Aug 2023, Pages 609-612, URL: https://www.ijscia.com/wp-content/uploads/2023/08/Volume4-Issue4-Jul-Aug-No.480-609-612.pdf

Volume 4 | Issue 4: Jul-Aug 2023