The Effectiveness of Oral Citicoline Administration as a Therapy for Memory Enhancement in Post-COVID-19 Patients: An Evidence-Based Case Report
Rindha Dwi Sihanto
Abstract
Background: Coronavirus Disease 2019 can cause both acute and chronic neurological problems, including cognitive impairment, which can develop at various times post-exposure and persist indefinitely. Citicoline is an alternative treatment option that can function as a neuroprotector. Objective: To determine the effectiveness of oral Citicoline administration as a therapy for memory enhancement in post-COVID-19 patients. Methods: A search was conducted on PubMed, Cochrane, EBSCOhost, Scopus, and Google Scholar for review articles and original studies. Researchers found only three studies linking Citicoline, COVID-19, and memory. Results: Turana et al. (2021) stated that Citicoline combats COVID-19-related cognitive decline through anti-inflammatory, antiviral, neuroprotective, neurorestorative, and acetylcholine neurotransmitter synthesis mechanisms. Al-Kuraishy (2022) concluded that Citicoline improves memory through mechanisms involving neural energy, neurogenesis, anti-inflammatory, antioxidant, and silent information regulator 1 (SIRT1). Zueva et al. (2021) reported that 18 (75%) COVID-19 patients with cognitive impairment who received Citicoline 1000 mg/day in an oral solution (100 mg / 1 ml) for 14 days showed significant memory improvement with p <0.05. This study reported that administering Citicoline 500 mg tablets every 12 hours for two months improved MoCA-INA scores by 16 points and MMSE scores by 13 points. Conclusion: Citicoline can be a significant consideration in memory therapy for post-COVID-19 patients.
Keywords
COVID-19; Citicoline; memory; neuroprotector.
Cite This Article
Sihanto, R. D. (2024). The Effectiveness of Oral Citicoline Administration as a Therapy for Memory Enhancement in Post-COVID-19 Patients: An Evidence-Based Case Report. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 4: Jul-Aug 2024, Pages 665-674, URL: https://www.ijscia.com/wp-content/uploads/2024/07/Volume5-Issue4-Jul-Aug-No.633-665-674.pdf
Volume 5 | Issue 4: Jul-Aug 2024
