The Potential of Propolis in Chronic Kidney Disease with Bone and Mineral Disorder: A Literature Review
Nathan Adia Abiati1, Joni Susanto2*
Abstract
Chronic kidney disease (CKD) is a heterogeneous syndrome characterized by a decline in glomerular filtration rate (GFR), an increase in serum creatinine within less than 7 days, and/or the presence of oliguria. Chronic kidney disease occurs progressively, evidenced by structural changes and a decline in kidney function for more than 3 months. The causes of chronic kidney disease are diverse, but there are two main pathophysiology underlying CKD: prolonged inflammation and oxidative stress. CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder) is one of the common complications that often occurs in CKD patients. It results from a disruption in the homeostasis of phosphate and calcium, leading to excessive resorption of bone matrix and potentially causing complications such as osteoporosis and vascular calcification. Propolis is a bee product with anti-inflammatory and antioxidant effects. Propolis has been proven effective as an adjunctive therapy for patients with chronic kidney disease. Additionally, propolis has protective effects on bones in various diseases, such as osteoporosis and fractures. However, to date, no studies have demonstrated the effects of propolis on bone in chronic kidney disease models.
Keywords
chronic kidney disease; bone; osteoblast; osteoclast; propolis.
Cite This Article
Abiati, N. A., Susanto, J. (2024). The Potential of Propolis in Chronic Kidney Disease with Bone and Mineral Disorder: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1359-1363, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.732-1359-1363.pdf
Volume 5 | Issue 6: Nov – Dec 2024
