The Role of The Ratio of Neutrophil Lymphocyte Platelet Lymphocyte and Lymphocyte Monocyte as A Prognostic Factor for Patients with Muscle Invasive Bladder Cancer at Prof Dr. I.G.N.G. Ngoerah Hospital Denpasar

Simon Ganesya Rahardjo^1*, ⁠I Wayan Yudiana², Tjokorda Gde Bagus Mahadewa³

Abstract

Background: Bladder cancer is the type of malignancy most frequently reported in the field of urology, where muscle-invasive bladder cancer (MIBC) accounts for around 25-30% of all cases with this malignancy. Bladder cancer morbidity and mortality are reported to be most common in Asia, where developing countries have a higher mortality-to-morbidity ratio. Several studies have shown the utility of simple laboratory inflammatory marker tests such as NLR, PLR, and LMR as predictors of outcomes in cases of other malignancies. Objective: To prove the value of NLR, PLR, and LMR can show the overall survival rate in post-cystectomy muscle-invasive bladder cancer patients. Method: This type of study is a retrospective cohort study to prove the value of NLR, PLR, and LMR as independent predictors in predicting outcomes in patients with MIBC. The sample was selected using consecutive sampling by selecting subjects who met the research criteria in the period January 2015 to December 2021 involving 50 MIBC patients who have undergone curative procedures at Prof. I. G. N. G Ngoerah Hospital Denpasar. Results: The chi-square test showed that there was a significant association between NLR and MIBC mortality (OR=24.8; 95%CI=2.75-223.2; p=0.001) and between PLR and MIBC mortality (OR=10.8; 95%CI=1.93-60.9; p=0.004). There was no relationship between LMR and MIBC mortality (p=0.561). Meanwhile, the results of multivariate analysis using the Cox regression test showed that high NLR was an independent predictor of MIBC mortality after controlling for confounding variables (OR=27.728; 95%CI=1.443-532.756; p=0.028). Conclusion: High NLR and PLR can indicate a poor overall survival rate in MIBC patients, but only NLR was proven to be significant as an independent predictor for the outcome of MIBC patients.

Keywords

bladder cancer; LMR; MIBC; NLR; PLR; Predictors.

Cite This Article

Rahardjo, S. G., Yudiana, I. W., Mahadewa, T. G. B.(2024). The Role of The Ratio of Neutrophil Lymphocyte Platelet Lymphocyte and Lymphocyte Monocyte as A Prognostic Factor for Patients with Muscle Invasive Bladder Cancer at Prof Dr. I.G.N.G. Ngoerah Hospital Denpasar. International Journal of Scientific Advances (IJSCIA), Volume 5| Issue 6: Nov-Dec 2024, Pages 1652-1663, URL: https://www.ijscia.com/wp-content/uploads/2024/12/Volume5-Issue6-Nov-Dec-No.785-1652-1663.pdf

Volume 5 | Issue 6: Nov – Dec 2024